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Print Share Butterbur Scientific Name s: Gaertner, Meyer and Scherb. Asteraceae Aster Common Name s: Blatterdockbog rhubarbbogshornsbutter-dockbutterburbutterfly dockcoltsfootexwortfuki Japanesepestilence-wortpestwurz GermanPetadolexPetaforceTesalinZE Medically reviewed on Jan 11, Uses Commercial preparations derived from butterbur include Petadolex available in the United States sinceTesalinand Petaforce.
A few small clinical trials some open label have shown some benefit in the treatment of migraines and allergic rhinitis. Dosing Trials in migraine, allergic rhinitis, and asthma have used butterbur extracts in dosages ranging from 50 to 75 mg twice daily.
Tesalin 16 to 32 mg in divided doses has been used in allergic rhinitis. Trials have included subjects 6 years of age and older. Contraindications Consider the use of butterbur-containing preparations in congestive heart failure a relative contraindication because of negative chronotropic effects demonstrated in animal experiments.
Preparations may contain liver toxins with carcinogenic and mutagenic potential. Interactions None well documented. Adverse Reactions GI symptoms comprise the majority of reported adverse reactions. Inhibition of testosterone production has been reported.
Toxicology Pyrrolizidine alkaloids found in butterbur are known liver toxins with carcinogenic and mutagenic potential.
Commercial dosage forms must be free of hepatotoxic pyrrolizidine alkaloids. Botany Butterbur is a perennial shrub native to Europe that has very large, downy leaves.
It commonly grows in wet, marshy ground or on sandbars near streams. The distinctive pink-lilac flowers grow on large spikes and appear before the leaves in spring. The name butterbur relates to the use of the leaves to wrap butter.
During the Middle Ages, butterbur leaves and roots were used to treat cough, plague, and fever. Other traditional uses include the treatment of gastric ulcer and bee stings.
High-performance liquid chromatography HPLC analyses of both plant parts indicate that, on average, leaves have lower alkaloid levels than roots. The petasin series of compounds is unstable in storage, with rearrangements occurring in dry plant materials and in stored extracts.
The biosynthesis of petasin has been elucidated. Both subjective and objective data serve as end points and measures of efficacy. Dosages used in these trials range from Tesalin 16 to 32 mg in divided doses and Petadolex mg in adults, with durations of 7 to 14 days.
Mechanisms of action for butterbur in allergic rhinitis relate to a role in leukotriene activity rather than an antihistaminic effect.Enzyme-based electrochemical biosensors for food safety: a review Harish Kumar, Rani Neelam Electrochemistry Laboratory, Department of Chemistry, Chaudhary Devi Lal University, Sirsa, Haryana, India Abstract: In recent years, food storage environment safety has been a major concern for food and health scientists.
There is growing interest in electrochemical biosensors due to their high. An assay is an investigative (analytic) procedure in laboratory medicine, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity (the analyte).
The analyte can be a drug, a biochemical substance, or a cell in an organism or organic sample. Defining Immunoassays The immunoassay is a technique which incorporates the binding reaction of a target substance (antigen) with an antibody. Antibodies are. To receive news and publication updates for Veterinary Medicine International, enter your email address in the box below.
The enzyme-linked immunosorbent assay (ELISA) (/ ɪ ˈ l aɪ z ə /, / ˌ iː ˈ l aɪ z ə /) is a commonly used analytical biochemistry assay, first described by Weiland in The assay uses a solid-phase enzyme immunoassay (EIA) to detect the presence of a ligand (commonly a protein) in a liquid sample using antibodies directed against the protein to be measured.
IONzyme: A novel enzyme mimetic. IONzyme exhibits peroxidase-like and catalase-like activities under physiological reaction conditions. The activities show typical catalytic features that are similar to natural enzymes, including substrate and optimal pH and temperature.